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KMID : 0359320160560020117
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Korean Journal of Veterinary Research
2016 Volume.56 No. 2 p.117 ~ p.120
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Appearance of osteoporosis in rat experimental autoimmune encephalomyelitis
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Ahn Mee-Jung
Kang So-Hi
Park Chan-Nam
Kim Jeong-Tae
Jung Kyung-Sook
Yang Mi-Young
Kim Sung-Ho
Moon Chang-Jong
Shin Tae-Kyun
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Abstract
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Experimental autoimmune encephalomyelitis (EAE) in Lewis rats is characterized by transient paralysis followed by recovery. To evaluate whether transient paralysis in EAE affects bone density, tibiae of EAE rats were morphologically investigated using micro-computed tomography and histology. The parameters of bone health were significantly reduced at the peak stage of EAE rats relative to those of controls (p < 0.05). The reduction of bone density was found to remain unchanged, even in the recovery stage. Collectively, the present data suggest that osteoporosis occurs in paralytic rats with monophasic EAE, possibly through the disuse of hindlimbs and/or autoimmune inflammation.
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KEYWORD
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autoimmunity, experimental autoimmune encephalomyelitis, micro-computed tomography, osteoporosis
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